Evolution by gene duplication: an update
نویسندگان
چکیده
منابع مشابه
Evolution by gene duplication: an update
The importance of gene duplication in supplying raw genetic material to biological evolution has been recognized since the 1930s. Recent genomic sequence data provide substantial evidence for the abundance of duplicated genes in all organisms surveyed. But how do newly duplicated genes survive and acquire novel functions, and what role does gene duplication play in the evolution of genomes and ...
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By considering the recent finding that unequal crossing over and other molecular interactions are contributing to the evolution of multigene families, a model of the origin of repetitive genes was studied by Monte Carlo simulations. Starting from a single gene copy, how genetic systems evolve was examined under unequal crossing over, random drift and natural selection. Both beneficial and deter...
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Recent studies reveal that transmenbrane (TM) topology (the number of TM segments (TMSs), the TMS position and the orientation of TMS to the membrane lipid bilayer) evolves by internal gene duplication [1, 6]. A large number of TM proteins, such as Bacteriorhodopsin, Na/Ca exchanger and the major facilitator superfamily, have been recognized to have internal repeats that presumably has arisen f...
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Lynch and Conery (1) presented one of the first serious efforts to study the evolutionary fate of gene duplication using genomic sequence data. Their analysis led to several interesting observations, particularly with respect to the rate of gene duplication in eukaryotic genomes and the subsequent halflife of duplicates. These two parameters are of particular importance in studying the evolutio...
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Relaxation of selective constraint is thought to play an important role for evolution by gene duplication, in connection with compensatory advantageous mutant substitutions. Models were investigated by incorporating gene duplication by unequal crossing over, selection, mutation and random genetic drift into Monte Carlo simulations. Compensatory advantageous mutations were introduced, and simula...
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ژورنال
عنوان ژورنال: Trends in Ecology & Evolution
سال: 2003
ISSN: 0169-5347
DOI: 10.1016/s0169-5347(03)00033-8